Mitochondrial Biotechnology via Genome Editing


화학세계 2024년 11월호 - 읽기 쉬운 총설: [미토콘드리아 유전자 교정의 발전과 연구동향]



Our group is researching cutting-edge biotechnology related to mitochondria and aiming to develop novel genome editing proteins for mitochondrial science. Mitochondrial DNA genome editing offers a remarkable opportunity to create animal models for human genetic disorders resulting from problematic mutations within the mitochondrial genome. Moreover, it holds promise for potential therapies using tools like DdCBEs, ZFD, TALED, and mitoBE, which involve DNA-binding proteins and DNA-modifying components like deaminase.

However, the practical use of mitochondrial base editors faces challenges like selectivity in sequences, unintended editing effects, and off-target impacts on both mitochondrial and nuclear DNA. Our team is dedicated to refining genome editing techniques through advanced protein engineering. This improvement in DNA editing tools is crucial for achieving effective genome modifications. Additionally, our goal involves generating mice with edited mitochondrial DNA carrying specific mitochondrial diseases, and exploring potential therapeutic mitochondrial DNA editing. By utilizing reliable tools to introduce point mutations in mouse embryos, we can explore the consequences of various mitochondrial DNA mutations.

Through our research, we aim to surpass these challenges and expand our insights into mitochondrial genetics and associated disorders. Our commitment is to pioneer innovative genome editing techniques that have the potential to transform mitochondrial medicine and disease research.

Join us in pushing the boundaries of mitochondrial genome editing and shaping the future of genetic medicine. If you have an interest in molecular biology, a passion for innovation, and a desire to make a lasting impact, we encourage you to apply and be a key player in this exciting journey of discovery. We are currently seeking highly motivated graduate students to embark on an exciting work! Contact to PI via e-mail.

저희 연구실에서는 미토콘드리아 유전자 교정을 통해 바이오헬스 분야의 여러 재미있는 연구를 진행하려고 합니다. 열정있는 학생들의 지원 바랍니다!